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89872

VEHICLE INFLUENCE ON OCULAR DISPOSITION OF CHLORTETRACYCLINE HYDROCHLORIDE AND CHLORAMPHENICOL IN THE ALBINO RABBIT

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Last updated: 25 Dec 2024

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Abstract

 The effect of four bases on the ocular disposition of chloramphenicol and chlortetracycline hydrochloride in the albino rabbits was investigated. It was found that the highest concentration of chlortetracycline hydrochloride in conjunctiva and cornea obtained from absorption base (A) and emulsion base (C). The absorption base (B) and emulsion base (C) were the only bases that can penetrate through the cornea into aqueous humor and irisciliary body. The emulsion base (D) give the highest chloramphenicol concentration in the conjunctiva in comparison with the other bases studied. Chloramphenicol appeared to be rapid uptake from all formulations and distributed across the cornea to the anterior chamber. Chloramphenicol uptake by conjunctiva from two emulsion bases (C and D) was more than from the other two absorption bases (A&B).

DOI

10.21608/bfsa.1984.89872

Authors

First Name

M.

Last Name

Attia

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut , Egypt

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Orcid

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First Name

H.

Last Name

El-Sourady

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut , Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

El-Shanawany

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut , Egypt

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Volume

7

Article Issue

2

Related Issue

13482

Issue Date

1984-12-01

Receive Date

1984-04-09

Publish Date

1984-12-31

Page Start

418

Page End

429

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 2_Pages 418-429.pdf

PDF . 401.9kB

Link

https://bpsa.journals.ekb.eg/article_89872.html

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https://bpsa.journals.ekb.eg/service?article_code=89872

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

VEHICLE INFLUENCE ON OCULAR DISPOSITION OF CHLORTETRACYCLINE HYDROCHLORIDE AND CHLORAMPHENICOL IN THE ALBINO RABBIT

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Article

Created At

22 Jan 2023