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89866

SOLUBILIZATION AND STABILITY OF CLONAZEPAM BY DIFFERENT CLASSES OF SURFACTANTS

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Last updated: 04 Jan 2025

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Abstract

Clonazepam a 1,4-benzodiazepine derivative acting as tranquillizer and hypnotic is practically water insoluble. It was solubilized by three different classes of surfactant solutions at pH 5,6,7 and 8 and of ionic strength (U) of 0.2. Sodium dodecyl sulphate (SDS), cetyl trimethyl ammonium bromide (CTAB) and Brij 35 were chosen for this study, which was carried out at 25, 35 and 65°. Neither the presence of the surfactant solutions in the concentrations used nor the presence of the degradation product (s) of clonazepam interfer in the spectrophotometric assay of the drug. At all the temperatures, and pH values investigated it was found that SDS solutions is the most efficient solubilizers for clonazepam followed by CTAB and Brij 35 solution respectively. Accelerated stability study of clonazepam was carried out in different concentrations of the last mentioned solutions at 65°. The half life (t½) of clonazepam was calculated in the prepared solutions and the longest t½  for clonazepam is in SDS solution of pH 6. The distribution coefficient (km) of clonazepam in the studied solutions was calculated from solubility and compared with the partition coefficient obtained from stability data (P@).

DOI

10.21608/bfsa.1984.89866

Authors

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Last Name

Simonelli

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P.

Affiliation

School of Pharmacy, University of Connecticut, STORRS, CT 06268, U.S.A.

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First Name

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Last Name

Aboutaleb

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E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

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Last Name

Abdel-Rahman

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A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

7

Article Issue

2

Related Issue

13482

Issue Date

1984-12-01

Receive Date

1983-12-22

Publish Date

1984-12-31

Page Start

363

Page End

379

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 2_Pages 363-379.pdf

PDF . 576.4kB

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https://bpsa.journals.ekb.eg/article_89866.html

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https://bpsa.journals.ekb.eg/service?article_code=89866

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

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https://bpsa.journals.ekb.eg/

MainTitle

SOLUBILIZATION AND STABILITY OF CLONAZEPAM BY DIFFERENT CLASSES OF SURFACTANTS

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Article

Created At

22 Jan 2023