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89702

FORMULATION AND STABILITY OF HEPTAMINOL SUPPOSITORIES PART III: Chemical Stability of Heptaminol Suppositories

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Last updated: 04 Jan 2025

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Abstract

The chemical stability of Heptaminol base in four different suppository bases was investigated in absence and presence of several stabilizers. The stability was found decreasing in the order of: Glycerogelatin, Cacao-Butter, Witepsol-E-75, and then Polyethylene-Glycols. Butylated hydroxyanisol (BHA) was the best stabilizer in the two fatty-based formulae, while tocopherol succinate was the worst. In the water-soluble bases, sodium thiosulphate was the best stabilizer, while the mixture of sodium formaldehyde sulfoxylate (SFS) with sodium edentate was the worst.

DOI

10.21608/bfsa.1984.89702

Authors

First Name

Ali

Last Name

Kassem

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

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Orcid

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First Name

Mohamed

Last Name

El-Miligi

MiddleName

F.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

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City

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Orcid

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First Name

Siham

Last Name

Ali

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

-

City

-

Orcid

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Volume

7

Article Issue

2

Related Issue

13482

Issue Date

1984-12-01

Receive Date

1983-02-10

Publish Date

1984-12-31

Page Start

288

Page End

294

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 2_Pages 288-294.pdf

PDF . 289.4kB

Link

https://bpsa.journals.ekb.eg/article_89702.html

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https://bpsa.journals.ekb.eg/service?article_code=89702

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND STABILITY OF HEPTAMINOL SUPPOSITORIES PART III: Chemical Stability of Heptaminol Suppositories

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Article

Created At

22 Jan 2023