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89691

FORMULATION AND STABILITY OF HEPTAMINOL INJECTABLE SOLUTION

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Last updated: 04 Jan 2025

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Abstract

The present work consists of a study of formulated aqueous injectable solutions of Heptaminol hydrochloride with respect to their physical and chemical stability as such, under different sterilization conditions, in presence, and in absence of antioxidants and bactericides. It was concluded that chlorocresol was incompatible with Heptaminol hydrochloride giving a pink colour. Also, inclusion of an antioxidant improved the shelf-life of Heptaminol injection. Sodium thiosulphate was regarded the first choice among the stabilizers tested. In addition, it was proved that different heat-sterilization techniques adopted variably influenced the medicament stability depending upon the particular antioxidant in the formula. Market injections were also tested and their stability was found to occupy the first place.

DOI

10.21608/bfsa.1984.89691

Authors

First Name

A.

Last Name

Kassem

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

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City

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Orcid

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First Name

M.

Last Name

El-Miligi

MiddleName

F.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

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City

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Orcid

-

First Name

S.

Last Name

Ali

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

-

City

-

Orcid

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Volume

7

Article Issue

2

Related Issue

13482

Issue Date

1984-12-01

Receive Date

1983-02-10

Publish Date

1984-12-31

Page Start

261

Page End

271

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 2_Pages 261-271.pdf

PDF . 432.8kB

Link

https://bpsa.journals.ekb.eg/article_89691.html

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https://bpsa.journals.ekb.eg/service?article_code=89691

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND STABILITY OF HEPTAMINOL INJECTABLE SOLUTION

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Article

Created At

22 Jan 2023