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89562

ADSORPTION OF ISONIAZID ON INSOLUBLE TABLET EXCIPIENTS AND CHARCOAL

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Last updated: 25 Dec 2024

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Abstract

 The adsorption of isoniazid onto the insoluble directly compressible tablet excipients : Emcotmpress, Avicel pH 101, Elcema P 50, P 100,  G 250, ethyl cellulose and STA-Rx as well as talc, magnesium stearate and charcoal was studied. The adsorption followed the Langmuir equation over initial concentrations of 80-200 mmole/L of isoniazid solution in water or in buffer solutions of pH 2.1 and 7.2. The adsorption capacities were of the following sequence: charcoal > starch > celluloses and talc > ethyl cellulose > emcompress. No measurable adsorption was noted on magnesium stearate or glassware. The possible mechanisms of adsorption were discussed. The kinetics of isoniazid release from compressed tablets using Emcompress, Avicel, ethyl cellulose and starch as the excipients did not correlate with the adsorption data, but the extent of release of drug had a good correlation with the adsorptive capacities of the excipients.

DOI

10.21608/bfsa.1984.89562

Authors

First Name

M.

Last Name

Mesiha

MiddleName

S.

Affiliation

Departments of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Shawky

MiddleName

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Affiliation

Departments of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

7

Article Issue

1

Related Issue

13462

Issue Date

1984-06-01

Receive Date

1983-04-27

Publish Date

1984-06-30

Page Start

173

Page End

189

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 1_Pages 173-189.pdf

PDF . 540.8kB

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https://bpsa.journals.ekb.eg/article_89562.html

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https://bpsa.journals.ekb.eg/service?article_code=89562

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ADSORPTION OF ISONIAZID ON INSOLUBLE TABLET EXCIPIENTS AND CHARCOAL

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Article

Created At

22 Jan 2023