Beta
ManageSearchChatDiscover
89535

FORMULATION AND STABILITY OF HEPTAMINOL SUPPOSITORIES

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The chemical stability of Heptaminol Base and of Heptaminol Hydrochloride was determined after shelf-life storage in an aqueous solution at room temperature. Under these conditions, the Base was found about 10.54 times more stable than the hydrochloride. Heptaminol Base, therefore, was formulated in four different suppository bases. The prepared suppositories were subjected to the usual quality control tests, both when fresh and after shelf-storage for one year. The results of physical examination were so variable that a sharp conclusion to a preferred formula was not possible, However, studies of medicament dissolution revealed that quick and full-dose release of heptaminol was achieved from glycerogelatin based suppositories. On the other hand, suppositories based with polyethylene glycols have shown a prolonged heptaminol dissolution rates. The chemical stability of the medicament In the four different suppository bases was also investigated in absence and presence of several, stabilizers. The stability was found decreasing in the order of: Clycerogelatin, Cacao-Butter, Witepsol-E-75, and then Poly-ethylene Glycols. Butylated hydroxyanisole (BHA) was the best stabilizer in the two fatty-based formulae, while tocopherol succinate was the best stabilizer, while the mixture of sodium formaldehyde sulfoxylate (SFS) with sodium edetate was the worst.

DOI

10.21608/bfsa.1984.89535

Authors

First Name

A.

Last Name

Kassem

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

El-Miligi

MiddleName

F.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Ali

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

-

City

-

Orcid

-

Volume

7

Article Issue

1

Related Issue

13462

Issue Date

1984-06-01

Receive Date

1983-02-10

Publish Date

1984-06-30

Page Start

122

Page End

142

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 1_Pages 122-142.pdf

PDF . 785.1kB

Link

https://bpsa.journals.ekb.eg/article_89535.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=89535

Order

9

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND STABILITY OF HEPTAMINOL SUPPOSITORIES

Details

Type

Article

Created At

22 Jan 2023