Beta
ManageSearchChatDiscover
89534

RETARDATION OF NITROFURANTOIN RELEASE BY COACERVATION

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Gelatin-acacia coacervation was employed to microencapsulate paraffin oil and soft paraffin droplets containing suspended nitrofurantoin, and for direct encapsulation of the drug. Dissolution characteristics of the encapsulated paraffin suspensions of nitrofurantoin, the directly encapsulated drug and nitrofurantoin powder were compared in buffer solutions of pH 1.12 and 7.2. The most rapid dissolution was shown by the nitrofurantoin powder followed by the directly encapsulated drug, the emulsified paraffin oil suspension of nitrofurantoin. The drug was released from oil-containing microcapsules in successive stages representing initial release from capsular layer followed by sustained release from the oily core material. Formalization of the gelatin-acacia coacervates should be allowed for enough time in order to obtain enteric protection. No correlation was found between the equilibrium solubility of the drug in the buffer and the corresponding release profile in the same buffer. The rate of release was slower as the viscosity of the core oil increased.

DOI

10.21608/bfsa.1984.89534

Authors

First Name

M.

Last Name

Mesiha

MiddleName

S.

Affiliation

Departments of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

H.

Last Name

El-Sourady

MiddleName

A.

Affiliation

Departments of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

7

Article Issue

1

Related Issue

13462

Issue Date

1984-06-01

Receive Date

1983-01-20

Publish Date

1984-06-30

Page Start

109

Page End

121

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 1_Pages 109-121.pdf

PDF . 466.4kB

Link

https://bpsa.journals.ekb.eg/article_89534.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=89534

Order

8

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

RETARDATION OF NITROFURANTOIN RELEASE BY COACERVATION

Details

Type

Article

Created At

22 Jan 2023