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89533

EFFECT OF SOME HYDROXYLATED ADDITIVES ON THE MICELLAR SOLUBILIZATION OF METHOTRIMEPRAZINE

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Last updated: 25 Dec 2024

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Abstract

The effect of different hydroxylated compounds on the solubility of Methotrimeprazine in non-ionic surfactant solutions was investigated at two different temperatures. Ethanol, glycerol, polyethylene glycol (PEG) 600 and PEG 4000, mannitol and sorbitol were studied as additives in systems containing Eumulgin C 1000, Eumulgin C 1500, Brij 35 and Brij 58 as the solubilizing surfactants. Micellar solubilization of Methotrimeprazine was found to be increased in Brij 35 systems with all additives except at low concentration (5% w/v) of PEG 600. It also increased in systems of Brij 58 containing PEG 600, PEG 4000, mannitol and sorbitol. A marked decrease in micellar solubilization of the drug was effected in systems of Eumulgine and Brij-58 containing ethanol or glycerol due to decreased micellization. Also, PEG 4000, mannitol and sorbitol decreased solubilizing effect of Eumulgine, except for PEG 4000 with Eumulgin C1000 at 35°.

DOI

10.21608/bfsa.1984.89533

Authors

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

M.

Last Name

Mesiha

MiddleName

S.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

Abdel-Zaher

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-

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

7

Article Issue

1

Related Issue

13462

Issue Date

1984-06-01

Receive Date

1983-01-10

Publish Date

1984-06-30

Page Start

97

Page End

108

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 1_Pages 97-108.pdf

PDF . 385.1kB

Link

https://bpsa.journals.ekb.eg/article_89533.html

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https://bpsa.journals.ekb.eg/service?article_code=89533

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7

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF SOME HYDROXYLATED ADDITIVES ON THE MICELLAR SOLUBILIZATION OF METHOTRIMEPRAZINE

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Article

Created At

22 Jan 2023