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89530

MANUFACTURE AND DISSOLUTION CHARACTERISTICS OF NEOMYCIN SULPHATE TABLETS

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Last updated: 25 Dec 2024

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Abstract

Some direct compression vehicles, viz., Avicel PH 101, Celutab, Sta-Rx 1500 Starch, Emcomress, and Solka-floc were employed in different concentrations for the preparation of neomycin sulphate tablets. The physical properties of the produced tablets were determined. The effect of incorporation of the different excipients on the dissolution characteristics of neomycin sulphate have been investigated. Neomycin sulphate tablets were successfully prepared by mixing with the suggested vehicles and drying before compression. Of the used vehicles, Celutab and Emcompress proved to be the best in improving the mechanical properties of the produced tablets. This improvement increased on increasing the proportion of the excipient. On the other hand, Avicel in spite of producing tablets having high hardness and low friability values, extended the disintegration time of the tablets. The drug dissoluted from these tablets very rapidly, but the rate decreased on increasing Avicel proportion.

DOI

10.21608/bfsa.1984.89530

Authors

First Name

M.

Last Name

Kassem

MiddleName

A.A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

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City

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Orcid

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First Name

M.

Last Name

El-Khatib

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

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City

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Orcid

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Volume

7

Article Issue

1

Related Issue

13462

Issue Date

1984-06-01

Receive Date

1983-01-06

Publish Date

1984-06-30

Page Start

75

Page End

96

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 1_Pages 75-96.pdf

PDF . 625.4kB

Link

https://bpsa.journals.ekb.eg/article_89530.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=89530

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6

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

MANUFACTURE AND DISSOLUTION CHARACTERISTICS OF NEOMYCIN SULPHATE TABLETS

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Article

Created At

22 Jan 2023