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89522

COLORIMETRIC DETERMINATION OF THYMOL, OXYPHENBUTAZONE AND MORPHINE HYDROCHLORIDE

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Last updated: 25 Dec 2024

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Abstract

A simple colorimetric method has been developed for the determination of thymol, oxyphenbutazone and morphine hydrochloride either in pure forms or in pharmaceutical preparations. The method is based on the formation of an azo dye from the condensation of diazotized 5-chloro-2,4-dinitroaniline with the titled drugs which contain a phenolic hydroxyl group. The absorption spectra for the coupling coloured products, for thymol, oxyphenbutazone and morphine hydrochloride exhibit absorption maxima at 592 nm (e= 46,153), 450 nm (e= 20,689) and 480 nm (e= 11,764) respectively. For each of the three studied drugs a typical calibration curve was obtained from linear regression analysis of absorbance at various drug concentrations. The developed colour for each drug was stable for at least 30 minutes. Optimum conditions for the colour formation have been determined. The application of this procedure to pharmaceutical preparations is given with good recoveries (99.69-100.50%).

DOI

10.21608/bfsa.1984.89522

Authors

First Name

S.

Last Name

El-Shabouri

MiddleName

R.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

Taha

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

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Orcid

-

First Name

B.

Last Name

Mohamed

MiddleName

B.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

7

Article Issue

1

Related Issue

13462

Issue Date

1984-06-01

Receive Date

1983-01-05

Publish Date

1984-06-30

Page Start

62

Page End

74

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 1_Pages 62-74.pdf

PDF . 449.3kB

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https://bpsa.journals.ekb.eg/article_89522.html

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https://bpsa.journals.ekb.eg/service?article_code=89522

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

COLORIMETRIC DETERMINATION OF THYMOL, OXYPHENBUTAZONE AND MORPHINE HYDROCHLORIDE

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Article

Created At

22 Jan 2023