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89521

PROLONGATION OF THE RELEASE OF EPHEDRINE HYDROCHLORIDE BY THE USE OF ANIONIC ACRYLIC RESINS

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Last updated: 25 Dec 2024

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Abstract

Eudragits S, L, RL and mixture of S and L were employed for prolonging the release of ephedrine hydrochloride from tablets by two different techniques, viz, spray coating and molecular dispersion. The in-vitro dissolution rate evaluation in both acid and alkaline media revealed that, tablets prepared with Eudragit-L showed the most prolonged release with t20% of 3½ and 4½ hours for spray coating and molecular dispersion methods respectively. Concerning the technique itself; drug-Eudragit molecular dispersion system showed a slower release than spray coating. Higuchi model for drug release could be applied for the release pattern only for few hours in case of tablets containing coated drug, while it absolutely explains the release from tablets having drug-Eudragit molecular dispersion system. Release was found to proceed according to order kinetics.

DOI

10.21608/bfsa.1984.89521

Authors

First Name

A.

Last Name

Nouh

MiddleName

T.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

-

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Orcid

-

First Name

M.

Last Name

Kassem

MiddleName

A.A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

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-

City

-

Orcid

-

First Name

Alaa

Last Name

Kassem

MiddleName

A.

Affiliation

Faculty of Pharmacy, El-Azhar University

Email

-

City

-

Orcid

-

First Name

G.

Last Name

Elmahrouk

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

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-

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-

Orcid

-

Volume

7

Article Issue

1

Related Issue

13462

Issue Date

1984-06-01

Receive Date

1982-12-30

Publish Date

1984-06-30

Page Start

47

Page End

61

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 1_Pages 47-61.pdf

PDF . 441.8kB

Link

https://bpsa.journals.ekb.eg/article_89521.html

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https://bpsa.journals.ekb.eg/service?article_code=89521

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4

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PROLONGATION OF THE RELEASE OF EPHEDRINE HYDROCHLORIDE BY THE USE OF ANIONIC ACRYLIC RESINS

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Article

Created At

22 Jan 2023