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89516

DETERMINATION OF ANTAZOLINE IN DOSAGE FORMS AND WITH NAPHAZOLINE IN COMBINATION

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Last updated: 04 Jan 2025

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Abstract

A simple and rapid spectrophotometric method is described for the determination of antazoline and naphazoline either singly or in combination. The method is based on the interaction of both drugs in the form of base with chloranil in acetonitrile at room temperature. The interaction products of antazoline and naphazoline exhibit two lmax, one at about 300 nm for both drugs and the other at 448 and 510 nm for antazoline and naphazoline respectively. Different variables have been studied to optimize the reaction conditions for both drugs. Beer's law is obeyed for both drugs over a range of 5-45 mg/ml. Interference studies are carried out and the application of this procedure for the determination of antazoline in single component tablets and in combination with naphazoline in nasal drops is given with good recovery range(99.4-99.9%). Synthetic mixtures of antazoline and naphazoline are satisfactorily analyzed simultaneously with good recoveries.

DOI

10.21608/bfsa.1984.89516

Authors

First Name

S.

Last Name

El-Shabouri

MiddleName

R.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

M.

Last Name

Amer

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

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Orcid

-

First Name

A.

Last Name

Taha

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

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Orcid

-

First Name

P.

Last Name

Khashaba

MiddleName

Y.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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Volume

7

Article Issue

1

Related Issue

13462

Issue Date

1984-06-01

Receive Date

1982-08-28

Publish Date

1984-06-30

Page Start

30

Page End

46

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 7_Issue 1_Pages 30-46.pdf

PDF . 570.0kB

Link

https://bpsa.journals.ekb.eg/article_89516.html

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https://bpsa.journals.ekb.eg/service?article_code=89516

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DETERMINATION OF ANTAZOLINE IN DOSAGE FORMS AND WITH NAPHAZOLINE IN COMBINATION

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Article

Created At

22 Jan 2023