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75904

IN-VITRO STUDY ON THE ADSORPTION OF RIFAMPICIN FROM AQUEOUS SOLUTION

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Last updated: 25 Dec 2024

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Abstract

The adsorption of rifampicin has been investigated onto kaolin, talc, magnesium trisilicate, magnesium oxide and avicel pH 101. Adsorption of rifampicin was markedly dependent on the nature of the adsorbent used. The amount of rifampicin adsorbed was found to be in obedience with both Langmuir and Freundlich equations. The extent of the amount adsorbed was correlated with the adsorbent structure. The decreasing order for the affinity of rifampicin to the selected adsorbents was as follows: kaolin > talc > magnesium trisilicate > avicel pH 101 > magnesium oxide. The effect of different concentrations of polysorbate 80 on the amount of rifampicin adsorbed onto activated charcoal surface has revealed that as the surfactant concentration was increased the amount of the drug adsorbed was correspondingly decreased. The mechanism through which the decrease in the extent of adsorption, in the presence of the surfactant, has been discussed.

DOI

10.21608/bfsa.1985.75904

Authors

First Name

Sayed

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

sayed.hussien@pharm.aun.edu.eg

City

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Orcid

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First Name

Sohair

Last Name

El-Shanawany

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

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Volume

8

Article Issue

2

Related Issue

11419

Issue Date

1985-12-01

Receive Date

1985-12-18

Publish Date

1985-12-31

Page Start

186

Page End

203

Print ISSN

1110-0052

Online ISSN

3009-7703

Link

https://bpsa.journals.ekb.eg/article_75904.html

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https://bpsa.journals.ekb.eg/service?article_code=75904

Order

13

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IN-VITRO STUDY ON THE ADSORPTION OF RIFAMPICIN FROM AQUEOUS SOLUTION

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Article

Created At

22 Jan 2023