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75903

INTERACTION OF 1,4-BENZODIAZEPINES WITH CERTAIN MACROMOLECULES: II- CRYSTALLIZATION OF TEMAZEPAM IN PRESENCE OF HYDROPHILIC MACROMOLECULES

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Last updated: 04 Jan 2025

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Abstract

Temazepam was crystallized from either ethanol or ethanol containing different concentrations of polysorbate 80, cetomacrogol 1000, Myrj 52 and PVP 40000 at 50°C. The produced treated crystals, as well as the untreated ones were subjected to solubility and computerized thermal studies, electron scanning microscopic examinations, determination of drug content and dissolution rates using particulate and intrinsic dissolution methods and employing recycling and automatic recording systems. Crystallization of the investigated drug from ethanol containing the afore-mentioned additives enhanced the dissolution rate to a varying extent, as demonstrated by a decrease in the T50% and the increase in the R.D.R. Decreasing the concentration of cetomacrogol 1000 and polysorbate 80 in the crystallization medium causes a gradual drop in dissolution rates. Thermal analysis of the produced crystals revealed a negligible change in melting points and a slight change in the enthalpy of fusion (DHf).

DOI

10.21608/bfsa.1985.75903

Authors

First Name

B.

Last Name

Mulley

MiddleName

A.

Affiliation

School of Pharmacy, Bradford University, England

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Orcid

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First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

Aly

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

-

Orcid

-

First Name

S.

Last Name

Ahmed

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt and School of Pharmacy, Bradford University, England

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City

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Volume

8

Article Issue

2

Related Issue

11419

Issue Date

1985-12-01

Receive Date

1985-12-10

Publish Date

1985-12-31

Page Start

171

Page End

185

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 8_Issue 2_Pages 171-185.pdf

PDF . 449.9kB

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https://bpsa.journals.ekb.eg/article_75903.html

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https://bpsa.journals.ekb.eg/service?article_code=75903

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INTERACTION OF 1,4-BENZODIAZEPINES WITH CERTAIN MACROMOLECULES: II- CRYSTALLIZATION OF TEMAZEPAM IN PRESENCE OF HYDROPHILIC MACROMOLECULES

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Article

Created At

22 Jan 2023