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75902

INTERACTION OF 1,4-BENZODIAZEPINES WITH CERTAIN MACROMOLECULES: I- EFFECT OF NON-IONIC SURFACTANTS ON THE DISSOLUTION RATE OF TEMAZEPAM

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Last updated: 25 Dec 2024

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Abstract

A recycling and automatic recording system was adopted for studying the dissolution of Temazepam via dispersed particulate and intrinsic dissolution methods. The study involves the effect of concentrations below and above CMC of polysorbates and Myris on the solubility and dissolution rate of Temazepam at 37°C. These Surfactants in low concentrations (below their CMC) caused no change in Temazepam solubility referred to its water solubility. T50% and RDR (relative dissolution rate) for Temazepam powder were calculated from the dissolution profiles. The presence of the studied surfactants in the dissolution medium caused an increase in the dissolution rate of the drug as demonstrated by a decrease in the T50% and the increase of the RDR. An explanation for these results is offered. The static disc method of dissolution was adopted in order to investigate the effect of the studied surfactants on the dissolution rate of Temazepam compressed discs. Plots of the amount of Temazepam dissolved, in the presence of the studied surfactants, as a function of time, were linear for the intrensic dissolution of Temazepam discs.  Correlation studies between the used surfactant concentrations and dissolution rate as well as solubility parameters of Temazepam were carried out and analyzed. It is suggested that the dissolution of Temazepam in the presence of the colloidal micellar surfactants is a diffusion controlled process and is related more to the diffusion layer mechanism of dissolution.

DOI

10.21608/bfsa.1985.75902

Authors

First Name

B.

Last Name

Mulley

MiddleName

A.

Affiliation

School of Pharmacy, Bradford University, England

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Orcid

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First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

Aly

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Ahmed

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt and School of Pharmacy, Bradford University, England

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City

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Volume

8

Article Issue

2

Related Issue

11419

Issue Date

1985-12-01

Receive Date

1985-12-02

Publish Date

1985-12-31

Page Start

158

Page End

170

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 8_Issue 2_Pages 158-170.pdf

PDF . 410.3kB

Link

https://bpsa.journals.ekb.eg/article_75902.html

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https://bpsa.journals.ekb.eg/service?article_code=75902

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INTERACTION OF 1,4-BENZODIAZEPINES WITH CERTAIN MACROMOLECULES: I- EFFECT OF NON-IONIC SURFACTANTS ON THE DISSOLUTION RATE OF TEMAZEPAM

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Article

Created At

22 Jan 2023