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75901

FORMULATION OF INFANTILE EPHEDRINE HYDROCHLORIDE SUPPOSITORIES

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Last updated: 25 Dec 2024

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Abstract

Ephedrine hydrochloride suppositories were prepared with non-ionic surfactants, and using Witepsol H15, Witepsol W35 and Witepsol E75. Mixtures of H15 + W35 and H15 + E75 in 1:1 ratio were also used. The prepared suppositories were evaluated for physical properties and release characteristics and were found to be base and surfactant dependant. Amount of drug released from the base mixture was found to be higher than those obtained with the individual base. Addition of non-ionic surfactants variably affects the amount of drug released depending on the nature and concentration of the surfactant used. Brij 72 and Myrj 45 were found to decrease the amount of drug released, however Tween 80 increased the release rate. The surfactant composition was found to affect the drug release. In conclusion, it was found that formulation of ephedrine hydrochloride in suppository form, suitable for infantile administration was possible.

DOI

10.21608/bfsa.1985.75901

Authors

First Name

A.

Last Name

Abd-El Gawad

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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First Name

A.

Last Name

Nouh

MiddleName

T.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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City

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Orcid

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First Name

M.

Last Name

El-Shaboury

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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Volume

8

Article Issue

2

Related Issue

11419

Issue Date

1985-12-01

Receive Date

1985-11-21

Publish Date

1985-12-31

Page Start

143

Page End

157

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 8_Issue 2_Pages 143-157.pdf

PDF . 500.7kB

Link

https://bpsa.journals.ekb.eg/article_75901.html

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https://bpsa.journals.ekb.eg/service?article_code=75901

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION OF INFANTILE EPHEDRINE HYDROCHLORIDE SUPPOSITORIES

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Article

Created At

22 Jan 2023