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75900

SPECTROPHOTOMETRIC DETERMINATION OF NITRAZEPAM IN TABLETS

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Last updated: 25 Dec 2024

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Abstract

A sensitive spectrophotometric method is reported for the determination of nitrazepam either pure or in tablets. The method is based on the reduction of nitrazepam with zinc dust and calcium chloride followed by reacting the reduced compound with trisodium pentacyanoaminoferrate. The reaction gives a violet product having an absorbance maximum at 560 nm. Beer's law is obeyed in the concentration range of 25-500 mg/ml of the reaction mixture. The common excipients in tablets do not interfere. The recovery and precision are similar to those of the official B.P. method.

DOI

10.21608/bfsa.1985.75900

Authors

First Name

Salwa

Last Name

El-Shabouri

MiddleName

Rizk

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

8

Article Issue

2

Related Issue

11419

Issue Date

1985-12-01

Receive Date

1985-11-07

Publish Date

1985-12-31

Page Start

134

Page End

142

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 8_Issue 2_Pages 134-142.pdf

PDF . 843.8kB

Link

https://bpsa.journals.ekb.eg/article_75900.html

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https://bpsa.journals.ekb.eg/service?article_code=75900

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC DETERMINATION OF NITRAZEPAM IN TABLETS

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Article

Created At

22 Jan 2023