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75899

COLORIMETRIC DETERMINATION OF CERTAIN TERTIARY AMINE DRUGS

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Last updated: 25 Dec 2024

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Abstract

A colorimetric method is developed for the determination of four tertiary amine salts; atropine sulphate, carbetapentane citrate, strychnine hydrochloride and climazole hydrochloride, both in pure forms and in pharmaceutical preparations. The method is based on the reaction of trinitrobenzene with ethyl acetoacetate in presence of each of the studied drugs as the free base. The absorption spectra for the developed color exhibit two maxima; one at 460 nm with higher molar absorptivity, and the other at 565 nm with lower molar absorptivity for all the studied drugs. The color formed obeys Beer's law at either wavelengths over a range of about 2-20 mg of the tertiary amine. Measurements are achieved at lmax 460 nm which is the most intense peak. Optimun conditions for the color formation have been studied and the application of this procedure to the corresponding pharmaceutical preparations is given.

DOI

10.21608/bfsa.1985.75899

Authors

First Name

S.

Last Name

El-Shabouri

MiddleName

R.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Hussin

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

-

First Name

A.

Last Name

Taha

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

-

Orcid

-

First Name

K.

Last Name

Imera

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

Orcid

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Volume

8

Article Issue

2

Related Issue

11419

Issue Date

1985-12-01

Receive Date

1985-10-15

Publish Date

1985-12-31

Page Start

120

Page End

133

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 8_Issue 2_Pages 120-133.pdf

PDF . 427.5kB

Link

https://bpsa.journals.ekb.eg/article_75899.html

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https://bpsa.journals.ekb.eg/service?article_code=75899

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8

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

COLORIMETRIC DETERMINATION OF CERTAIN TERTIARY AMINE DRUGS

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Article

Created At

22 Jan 2023