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75898

PREPARATION AND EVALUATION OF DIRECTLY COMPRESSED MEDAZEPAM HYDROCHLORIDE TABLETS

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Last updated: 25 Dec 2024

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Abstract

Medazepam, the well known benzodiazepine derivative used as a tranquilizer and in alcohol withdrawal, was prepared in directly compressed tablets. The directly compressible vehicles which were used singly or in binary blends 1:1, were Avicel, Lactose, STA-Rx 1500, Emcompress and the recently introduced vehicle, Compactrol. It was found that Avicel and Emcompress represent the most suitable efficient single vehicles used for the preparation of Medazepam hydrochloride tablets. In case of binary blends it was found that the best quality batches were prepared using Avicel : Emcompress blend 1:1. Physical characteristics including uniformity of weight, thickness, hardness, friability were investigated for the prepared batches. The effect of directly compressible vehicle variation on the uniformity of drug content and the dissolution rates of Medazepam hydrochloride tablets was also studied.

DOI

10.21608/bfsa.1985.75898

Authors

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

Aly

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

S.

Last Name

Saleh

MiddleName

I.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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Orcid

-

First Name

M.

Last Name

Ahmed

MiddleName

O.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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Orcid

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Volume

8

Article Issue

2

Related Issue

11419

Issue Date

1985-12-01

Receive Date

1985-09-25

Publish Date

1985-12-31

Page Start

104

Page End

119

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 8_Issue 2_Pages 104-119.pdf

PDF . 480.5kB

Link

https://bpsa.journals.ekb.eg/article_75898.html

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https://bpsa.journals.ekb.eg/service?article_code=75898

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PREPARATION AND EVALUATION OF DIRECTLY COMPRESSED MEDAZEPAM HYDROCHLORIDE TABLETS

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Article

Created At

22 Jan 2023