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75897

EVALUATION AND BIOAVAILABILITY OF PHENAZOPYRIDINE HYDROCHLORIDE TABLETS PREPARED WITH COMPACTROL

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Last updated: 04 Jan 2025

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Abstract

 Phenazopyridine hydrochloride tablets were prepared at different packing fractions using the newly introduced direct compressible vehicle "compactrol". Tablets were also prepared with avicel and wet granulation technique for comparison. The physical standards and dissolution rate of the produced tablets were investigated. Also the In-Vivo study for tablets having the highest mechanical strength was carried out. The results revealed that increasing the packing fraction was followed by an increase in tablet hardness and a decrease in friability percent. Also the disintegration time for tablets prepared by wet granulation technique was increased. However, the dissolution rate of all the produced tablets was slightly affected by the increase in the packing fraction. Compactrol produced the hardest tablets (6 Kg), of the shortest disintegration time (0.17 min.). As regards the bioavailability, avicel produced tablets with the highest bioavailability. On the other hand, the bioavailability of tablets prepared with compactrol and wet granulation was similar. Thus, phenazopyridine tablets can be prepared by direct compression technique to ensure highest mechanical strength and highest bioavailability.

DOI

10.21608/bfsa.1985.75897

Authors

First Name

Hamdy

Last Name

Abdel-Aleem

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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First Name

Mohamed

Last Name

Elshaboury

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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First Name

Abdel-Gawad

Last Name

Abdel-Gawad

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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Volume

8

Article Issue

2

Related Issue

11419

Issue Date

1985-12-01

Receive Date

1985-08-17

Publish Date

1985-12-31

Page Start

88

Page End

103

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 8_Issue 2_Pages 88-103.pdf

PDF . 398.9kB

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https://bpsa.journals.ekb.eg/article_75897.html

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https://bpsa.journals.ekb.eg/service?article_code=75897

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EVALUATION AND BIOAVAILABILITY OF PHENAZOPYRIDINE HYDROCHLORIDE TABLETS PREPARED WITH COMPACTROL

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Article

Created At

22 Jan 2023