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75896

SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF PROMETHAZINE HYDROCHLORIDE AND THIETHYLPERAZINE MALEATE IN PHARMACEUTICAL PREPARATIONS

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Last updated: 25 Dec 2024

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Abstract

A new spectrophotometric method for the determination of promethazine HCl and thiethylperazine maleats is presented. The method is based on the interaction of each drug with benzocaine and N-bromosuccinimide at room temperature to produce a blue colour. Optimum conditions for colour development and possible interferences have been studied. The proposed method has been applied to the analysis of both drugs in pharmaceutical preparations, the results of which are in good agreement with those obtained by the official methods of B.P. and U.S.P.

DOI

10.21608/bfsa.1985.75896

Authors

First Name

S.

Last Name

El-Shabouri

MiddleName

R.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

Youssef

MiddleName

F.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

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Orcid

-

First Name

F.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

-

Orcid

-

First Name

A.

Last Name

Rageh

MiddleName

I.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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Volume

8

Article Issue

2

Related Issue

11419

Issue Date

1985-12-01

Receive Date

1985-08-15

Publish Date

1985-12-31

Page Start

70

Page End

87

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 8_Issue 2_Pages 70-87.pdf

PDF . 464.1kB

Link

https://bpsa.journals.ekb.eg/article_75896.html

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https://bpsa.journals.ekb.eg/service?article_code=75896

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF PROMETHAZINE HYDROCHLORIDE AND THIETHYLPERAZINE MALEATE IN PHARMACEUTICAL PREPARATIONS

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Article

Created At

22 Jan 2023