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75894

COMPARATIVE STUDY ON THE PHYSICO-CHEMICAL STABILITY OF ACETYLSALICYLIC ACID TABLETS PREPARED BY MICROENCAPSULATION AND OTHER PREPARATIVE TECHNIQUES

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Last updated: 25 Dec 2024

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Abstract

Acetylsalicylic acid (ASA) tablets were prepared using microencapsulation, wet-granulation with hydroalcohlic gelatin dispersion and direct compression using emdex and avicel. Commercially available microencapsulated ASA tablets were used for the comparative study. Batches of tablets that showed good physical and mechanical properties and dissolution characteristics were selected for the stability study. Stability testing was carried out at ambient conditions, 52% R.H. at 20°C and finally at 95% R.H. at the same temperatures. The results were recorded at the start of the accelerated stability investigation and after subsequent one month intervals for six months storage time period. The rate of decomposition under these stress conditions was determined. There was a significant increase in tablets weight, thickness, friability percent and disintegration time. However, a marked decrease in tablet hardness and dissolution rate was observed. Maximum stability was obtained for ASA tablets directly compressed with avicel and by wet-granulation. Emdex could be considered as the most suitable vehicle at low humidity for stability of ASA tablets. The hydrolytic decomposition of the prepared tablets followed the first order pathway. Both prepared and commercial microencapsulated ASA tablets were not suitable for storage at high humidity level.

DOI

10.21608/bfsa.1985.75894

Authors

First Name

Ahmed

Last Name

Nouh

MiddleName

T.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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Orcid

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First Name

H.

Last Name

El-Sabbagh

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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City

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Orcid

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First Name

A.

Last Name

Abd El-Gawad

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

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City

-

Orcid

-

First Name

M.

Last Name

El-Shaboury

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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City

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Orcid

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Volume

8

Article Issue

2

Related Issue

11419

Issue Date

1985-12-01

Receive Date

1985-05-14

Publish Date

1985-12-31

Page Start

25

Page End

46

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 8_Issue 2_Pages 25-46.pdf

PDF . 746.1kB

Link

https://bpsa.journals.ekb.eg/article_75894.html

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https://bpsa.journals.ekb.eg/service?article_code=75894

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

COMPARATIVE STUDY ON THE PHYSICO-CHEMICAL STABILITY OF ACETYLSALICYLIC ACID TABLETS PREPARED BY MICROENCAPSULATION AND OTHER PREPARATIVE TECHNIQUES

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Article

Created At

22 Jan 2023