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75892

A CAST FILM APPROACH TO THE STUDY OF IN-VITRO DRUG RELEASE FROM OINTMENTS AND CREAMS

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Last updated: 25 Dec 2024

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Abstract

The release rate of Nystation from a casted film of Amphocerin-E and Dehymuls-K ointment bases was investigated. The role of surfactants in enhancing the drug release was also studied. The rate of release of the drug from Dehymuls-K was found markedly higher than that of Amphocerin-E. The surfactants used markedly increase the release rate of the drug from the bases. Sodium lauryl sulfate, whether present in the casted film base or in the aqueous release medium enhances the rate of release of Nystation when compared to cetrimide. The effect of surfactant is more pronounced if it was added to the release medium than when incorporated in the casted base film. Higuchi model was applied for all experimental release data, where a good correlation was observed.

DOI

10.21608/bfsa.1985.75892

Authors

First Name

Ahmed

Last Name

Nouh

MiddleName

T.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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City

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Orcid

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First Name

Esmat

Last Name

El-Deen

MiddleName

Z.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

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City

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Orcid

-

First Name

M.

Last Name

Hanaa Mahmoud

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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City

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Orcid

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Volume

8

Article Issue

2

Related Issue

11419

Issue Date

1985-12-01

Receive Date

1985-05-14

Publish Date

1985-12-31

Page Start

12

Page End

24

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 8_Issue 2_Pages 12-24.pdf

PDF . 340.0kB

Link

https://bpsa.journals.ekb.eg/article_75892.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=75892

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

A CAST FILM APPROACH TO THE STUDY OF IN-VITRO DRUG RELEASE FROM OINTMENTS AND CREAMS

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Article

Created At

22 Jan 2023