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75889

SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN BENZODIAZEPINE DRUGS

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Last updated: 25 Dec 2024

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Abstract

A rapid adequate spectrophotometric method was developed for the quantitative determination of diazepam, nordiazepam, oxazepam and chlordiazepoxide in pure form and in pharmaceutical preparations. The method is based on the hydrolysis of the above mentioned drugs in acid medium for 20 minutes in a boiling water bath. The formed amines were condensed with p-dimethylaminocinnamaldehyde in acidic methanol to form pink coloured product with absorption maxima at 500 and 530 nm for diazepam and the other drugs respectively. Beer's law was obeyed over the range of 0.5-10 mg ml-1 for all studied drugs. The produced colour is stable for 2 hours for diazepam and at least for 24 hours for the other studied drugs. The method is simple, sensitive and particularly suited for routine analysis of these drugs.

DOI

10.21608/bfsa.1985.75889

Authors

First Name

S.

Last Name

El-Shabouri

MiddleName

R.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

M.

Last Name

Sidhom

MiddleName

B.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

8

Article Issue

1

Related Issue

11392

Issue Date

1985-06-01

Receive Date

1985-04-07

Publish Date

1985-06-30

Page Start

156

Page End

171

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 8_Issue 1_Pages 156-171.pdf

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https://bpsa.journals.ekb.eg/article_75889.html

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https://bpsa.journals.ekb.eg/service?article_code=75889

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN BENZODIAZEPINE DRUGS

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Article

Created At

22 Jan 2023