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74587

INTERACTION OF 1,4-BENZODIAZEPINES WITH HYDROPHILIC MACROMOLECULES: V- WETTABILITY OF MODIFIED TEMAZEPAM CRYSTALS

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Last updated: 04 Jan 2025

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Abstract

Wettability of temazepam crystals, crystallized from different concentrations of polysorbate 80 and cetomacrogol 1000 was evaluated quantitatively by measuring the contact angles on compressed discs of the crystallized drug. Increasing the concentration of the surfactant from which the drug was crystallized leads to increase in wettability. A direct correlation was found between the wettability of the drug and its dissolution. An agreement was observed between the values of the contact angles measured using the adopted and the photographic methods. The effect of time on the contact angle values was also investigated.

DOI

10.21608/bfsa.1986.74587

Authors

First Name

B.

Last Name

Mulley

MiddleName

A.

Affiliation

School of Pharmacy, Bradford University, U.K

Email

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City

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Orcid

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First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Aly

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Ahmed

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

9

Article Issue

2

Related Issue

11260

Issue Date

1986-12-01

Receive Date

1986-10-09

Publish Date

1986-12-31

Page Start

157

Page End

171

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 2_Pages 157-171.pdf

PDF . 470.5kB

Link

https://bpsa.journals.ekb.eg/article_74587.html

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https://bpsa.journals.ekb.eg/service?article_code=74587

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INTERACTION OF 1,4-BENZODIAZEPINES WITH HYDROPHILIC MACROMOLECULES: V- WETTABILITY OF MODIFIED TEMAZEPAM CRYSTALS

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Article

Created At

22 Jan 2023