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74586

ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES 1- POLYSORBATES

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Last updated: 04 Jan 2025

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Abstract

The permeation rates of rifampicin through a standard cellophane membrane were investigated in presence of different polysorbates. The surfactants were used in a concentration range of 0.2-0.6% w/v. The data revealed that as the surfactant concentration was increased, the diffusion rates were found to be decreased. This was explained on the basis that as the surfactant concentration was increased, the partial volume fraction was consequently increased and a large amount of rifampicin was incorporated inside the micellar core. These incorporated rifampicin molecules are not ready to permeate through the membrane. The Langmuir plots as well as spectrophotometric analysis indicate that a complex formed between rifampicin and the tested polysorbates. This complex is not ready, also, to penetrate through the membrane. It was found that the limiting adsorption capacities of surfactants were almost the same. This was explained on the basis that they are characterized by having the same number of oxyethylene unites.

DOI

10.21608/bfsa.1986.74586

Authors

First Name

F.

Last Name

Habib

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

lsmail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

S.

Last Name

El-Shanawany

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

E.

Last Name

Fouad

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

9

Article Issue

2

Related Issue

11260

Issue Date

1986-12-01

Receive Date

1986-10-04

Publish Date

1986-12-31

Page Start

144

Page End

156

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 2_Pages 144-156.pdf

PDF . 389.8kB

Link

https://bpsa.journals.ekb.eg/article_74586.html

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https://bpsa.journals.ekb.eg/service?article_code=74586

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES 1- POLYSORBATES

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Article

Created At

22 Jan 2023