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74580

TITRIMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE AND FLUBENDAZOLE USING N-BROMOSUCCINIMIDE

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Last updated: 25 Dec 2024

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Abstract

Titrimetric and spectrophotometric determination methods are described for mebendazole and flubendazole in dosage forms. The first method depends upon addition of an excess of standard N-bromosuccinimide (NBS) and after the specified time, the residual reagent is determined iodometrically. This procedure permits semi-micro determination (3-30 mg) of the drug. An alternative procedure involves measurement of the colour produced after reaction with N-bromosuccinimide (lmax 465 nm). The stoichiometry of the reaction was studied and found 1:1 for mebendazole- NBS and 1:2 for flubendazole-NBS. The methods were applied successfully for the analysis of either of the two drugs in some formulations. Average recoveries ranging from 98.70±1.64 to 101.94±0.82 for titrimetric and from 97.5 ± 0.65 to 101.30± 0.55 for spectrophotometric methods were obtained. The methods were compared with U.S.P. XX method in case of mebendazole and were found in good agreement.

DOI

10.21608/bfsa.1986.74580

Authors

First Name

F.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

M.

Last Name

Sidhom

MiddleName

B.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

S.

Last Name

Hussein

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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Volume

9

Article Issue

2

Related Issue

11260

Issue Date

1986-12-01

Receive Date

1986-07-22

Publish Date

1986-12-31

Page Start

92

Page End

104

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 2_Pages 92-104.pdf

PDF . 353.1kB

Link

https://bpsa.journals.ekb.eg/article_74580.html

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https://bpsa.journals.ekb.eg/service?article_code=74580

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

TITRIMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE AND FLUBENDAZOLE USING N-BROMOSUCCINIMIDE

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Created At

22 Jan 2023