Beta
ManageSearchChatDiscover
74573

FORMULATION AND EVALUATION OF CERTAIN ANTI-INFLAMMATORY DRUGS FOR TOPICAL APPLICATION. 1- OINTMENT FORMS

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The influence of type of vehicle on the in-vitro and anti-inflammatory effect of flufenamic and mefenamic acids has been studied. The vehicle investigated consisted of: water soluble base, an absorption base and two emulsion bases (O/W and W/O). In-vitro release was evaluated using a diffusion assembly fitted with Fischer cellulose membrane (30/32) as diffusion barrier. Phosphate buffer of pH 6.8 at 35° C (±2) was used as release medium. The results revealed that, the rate and amount of drug released was greatly affected by the type of base and nature of drug. The ointment bases can be arranged according to in-vitro release for both flufenamic and mefenamic acids as follows: water-soluble base > water-in oil emulsion base > oil in-water emulsion base > absorption base. Anti-inflammatory effect was studied on inflamed tissue of albino rabbit. The selected ointment bases were uniformly spread over the shaved inflamed back skin of rabbit for several days. The ointment bases can be arranged in descending order according to anti-inflammatory effect after topical application to inflamed tissue as follows: Absorption base > water in-oil emulsion base > oil-in-water emulsion base> water soluble base. Trials to find out any correlation between in-vitro release and anti-inflammatory effect for both flufenamic and mefenamic acids were carried out. It was found that there is only correlation between in-vitro release and anti-inflammatory effect for emulsion base (W/O, O/W) for both flufenamic and mefenamic acids.

DOI

10.21608/bfsa.1986.74573

Authors

First Name

S.

Last Name

El-Shanawany

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Safwat

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

9

Article Issue

2

Related Issue

11260

Issue Date

1986-12-01

Receive Date

1986-06-03

Publish Date

1986-12-31

Page Start

50

Page End

65

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 2_Pages 50-65.pdf

PDF . 448.0kB

Link

https://bpsa.journals.ekb.eg/article_74573.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=74573

Order

4

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND EVALUATION OF CERTAIN ANTI-INFLAMMATORY DRUGS FOR TOPICAL APPLICATION. 1- OINTMENT FORMS

Details

Type

Article

Created At

22 Jan 2023