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74572

BIOAVAILABILITY AND EROSIVE ACTIVITY OF SOME NON-STEROIDAL ANTI-INFLAMMATORY DRUGS SOLID-DISPERSIONS

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Last updated: 25 Dec 2024

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Abstract

Solid dispersions of mefenamic acid, azapropazone, glafenine and floctafenine were prepared with PVP K25 and PEG 6000 in a ratio of 1:1 w/w. Bioavailability and erosive activity of these drugs were investigated using their solid dispersions. The obtained results revealed that the coprecipitate of such drugs with PVP enhances their bioavailability and significantly inhibits the ulcerogenic effect of the drugs under investigation. However, solid dispersions with PEG enhance bioavailability but slightly reduce their gastric ulceration.

DOI

10.21608/bfsa.1986.74572

Authors

First Name

E.

Last Name

Ramadan

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

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City

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Orcid

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First Name

A. G.

Last Name

Abd El-Gawad

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Nouh

MiddleName

T.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

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Volume

9

Article Issue

2

Related Issue

11260

Issue Date

1986-12-01

Receive Date

1986-06-03

Publish Date

1986-12-31

Page Start

30

Page End

49

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 2_Pages 30-49.pdf

PDF . 968.3kB

Link

https://bpsa.journals.ekb.eg/article_74572.html

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https://bpsa.journals.ekb.eg/service?article_code=74572

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

BIOAVAILABILITY AND EROSIVE ACTIVITY OF SOME NON-STEROIDAL ANTI-INFLAMMATORY DRUGS SOLID-DISPERSIONS

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Article

Created At

22 Jan 2023