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74571

IN-VIVO ELIMINATION OF DIHYDROPYRIDINE DRUG DELIVERY CARRIERS FROM BRAIN AND BLOOD OF RATS

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Last updated: 25 Dec 2024

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Abstract

The dihydropyridine « pyridinium salt redox delivery system, used for specific delivery and sustained release of drugs in the brain was studied. The rates of elimination of the ester and acid metabolites of l-methyl- 3-(ethoxycarbonyl)-1,4-dihydrpyridine and of 1-(2-ethoxycarbonyl) ethyl-1,4-dihydronicotinamide from brain and blood of rats after systemic administration of dihydro carrier-ethanol couples were investigated, taking ethanol as a model drug. It was found that the quaternary species are eliminated relatively fast, which supports the hypothesis for existence of an active transport mechanism for eliminating organic ions from the brain. The results can serve as a primary evidence for the suggestion that the carrier and its metabolites will not impair central nervous system functions.

DOI

10.21608/bfsa.1986.74571

Authors

First Name

N.

Last Name

Bodor

MiddleName

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Affiliation

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, U.S.A

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First Name

M.

Last Name

El-Kommos

MiddleName

E.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

-

First Name

Ch.

Last Name

Nath

MiddleName

-

Affiliation

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, U.S.A

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Volume

9

Article Issue

2

Related Issue

11260

Issue Date

1986-12-01

Receive Date

1986-04-28

Publish Date

1986-12-31

Page Start

14

Page End

29

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 2_Pages 14-29.pdf

PDF . 442.9kB

Link

https://bpsa.journals.ekb.eg/article_74571.html

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https://bpsa.journals.ekb.eg/service?article_code=74571

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IN-VIVO ELIMINATION OF DIHYDROPYRIDINE DRUG DELIVERY CARRIERS FROM BRAIN AND BLOOD OF RATS

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Article

Created At

22 Jan 2023