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74480

COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS 3- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND CERTAIN PHYSICOCHEMICAL PARAMETERS OF RING SUBSTITUENTS

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Last updated: 04 Jan 2025

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Abstract

The color intensity developed from the reaction of twelve phenothiazine drugs with I3 has been correlated using physicochemical substituent like Hammett constant sp, and molecular connectivity 1Xv. Results indicated a predominant role of electronic parameter in determining color intensity. The bulkiness described by 1Xv played a significant role. However, other parameters of the side chain were also prominent. Working up multiple parametric regression can be used as a reliable tool to predict the sensitivity and scope of the colorimetric method for other phenothiazines.

DOI

10.21608/bfsa.1986.74480

Authors

First Name

S.

Last Name

El-Shabouri

MiddleName

R.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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First Name

A.

Last Name

Youssef

MiddleName

F.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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City

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Orcid

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First Name

F.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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City

-

Orcid

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First Name

A-M.

Last Name

Rageh

MiddleName

I.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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Volume

9

Article Issue

1

Related Issue

11257

Issue Date

1986-06-01

Receive Date

1986-03-25

Publish Date

1986-06-30

Page Start

137

Page End

148

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 1_Pages 137-148.pdf

PDF . 337.4kB

Link

https://bpsa.journals.ekb.eg/article_74480.html

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https://bpsa.journals.ekb.eg/service?article_code=74480

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS 3- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND CERTAIN PHYSICOCHEMICAL PARAMETERS OF RING SUBSTITUENTS

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Article

Created At

22 Jan 2023