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74479

KINETICS OF ASPIRIN HYDROLYSIS IN AQUEOUS SOLUTION OF SURFACTANTS I- NON-IONIC SURFACTANTS

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Last updated: 04 Jan 2025

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Abstract

The kinetics of aspirin hydrolysis were studied in the presence of different concentrations of polysorbates and at a variety of pH range. The aspirin hydrolysis in the presence of polysorbates followed first-order kinetics and the observed rate constants at different pH values and in the presence of the surface-active aaents were calculated. The surfactant effect ratio (SER) was calculated and found to be decreased as the surfactant concentration was increased. The micellar rate constant, Km , for the drug in the presence of the tested surfactants at a given pH value as well-as the distribution coefficient, K, of aspirin between the micellar and the aqueous phases were estimated. From the results obtained, it could be observed that the Km and K values are markedly influenced by the pH value of the system. The study revealed that the surfactants are not only used to solubilize those poorly water soluble compounds but also to increase their stability in aqueous solutions.

DOI

10.21608/bfsa.1986.74479

Authors

First Name

S.

Last Name

Ismail

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

Simonelli

MiddleName

P.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, University of Connecticut, USA

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Volume

9

Article Issue

1

Related Issue

11257

Issue Date

1986-06-01

Receive Date

1986-03-24

Publish Date

1986-06-30

Page Start

119

Page End

136

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 1_Pages 119-136.pdf

PDF . 563.9kB

Link

https://bpsa.journals.ekb.eg/article_74479.html

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https://bpsa.journals.ekb.eg/service?article_code=74479

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9

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

KINETICS OF ASPIRIN HYDROLYSIS IN AQUEOUS SOLUTION OF SURFACTANTS I- NON-IONIC SURFACTANTS

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Article

Created At

22 Jan 2023