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74476

FORMULATION OF AZAPROPAZONE SUPPOSITORIES AND EXAMINATION OF ITS EFFECT ON THE GASTROINTESTINAL TRACT OF RABBITS

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Last updated: 04 Jan 2025

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Abstract

The rectal absorption of azapropazone, in rabbits, from different suppository formulations was investigated, and compared with its in-vitro release. A comparison between the rectal absorption of the drug and its absorption from capsule was done. The effect of azapropazone on the gastrointestinal tract of rabbits was studied. It was proved that the rectal absorption of the drug is a function of the nature or suppository bases. Of the tested bases, a base consisting of a mixture of PEG 6000, 1540 and 400 (47:33:20) gave the highest in-vitro release, however Witepsol Hl5 produced the highest rectal absorption of the medicament. The availability of azapropazone from the capsules was much better than that from the suppositories. The effect of the orally and rectally administered drug on the duodenal mucosa was deleterious with a marked ulceration. No ulcerative changes could be detected on the rectal mucosa in any of the tested groups of rabbits. On the gastric mucosa, there was a pronounced ulcerative changes in case of oral administration

DOI

10.21608/bfsa.1986.74476

Authors

First Name

A.

Last Name

Nouh

MiddleName

T. I.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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Orcid

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First Name

E.

Last Name

Ramadan

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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Orcid

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First Name

A.

Last Name

Abdel-Gawad

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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Volume

9

Article Issue

1

Related Issue

11257

Issue Date

1986-06-01

Receive Date

1986-01-29

Publish Date

1986-06-30

Page Start

71

Page End

88

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 1_Pages 71-88.pdf

PDF . 700.0kB

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https://bpsa.journals.ekb.eg/article_74476.html

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https://bpsa.journals.ekb.eg/service?article_code=74476

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION OF AZAPROPAZONE SUPPOSITORIES AND EXAMINATION OF ITS EFFECT ON THE GASTROINTESTINAL TRACT OF RABBITS

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Article

Created At

22 Jan 2023