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74475

DISSOLUTION BEHAVIOUR OF TOLAZAMIDE IN THE PRESENCE OF CERTAIN NON-IONIC SURFACTANTS

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Last updated: 25 Dec 2024

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Abstract

The dissolution rate of tolazamide, on oral hypoglycemic drug, was studied in distilled water as well as solutions of polysorbates and myrjs at 30°C using the beaker method. The surfactant concentration was increased from 0.001 to 0.5% W/V in order to study the effect of the surfactant concentration on the dissolution rate of tolazamide. The relative area under the curve, from0-60 minutes (R.A.U.C.0-60) was used as a parameter to compare the effect of different surfactants, used at the same concentration (0.5% W/V), on the dissolution rate of tolazamide. It was found that the amount of the drug dissolved was significantly dependent on the concentration of each surfactant used as well as the type of the surfactant. The mechanism of the increase in the dissolution rate was also discussed.

DOI

10.21608/bfsa.1986.74475

Authors

First Name

Sayed

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

sayed.hussien@pharm.aun.edu.eg

City

-

Orcid

-

First Name

Ali

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

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Volume

9

Article Issue

1

Related Issue

11257

Issue Date

1986-06-01

Receive Date

1986-01-25

Publish Date

1986-06-30

Page Start

60

Page End

70

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 1_Pages 60-70.pdf

PDF . 332.7kB

Link

https://bpsa.journals.ekb.eg/article_74475.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=74475

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DISSOLUTION BEHAVIOUR OF TOLAZAMIDE IN THE PRESENCE OF CERTAIN NON-IONIC SURFACTANTS

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Article

Created At

22 Jan 2023