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74474

EFFECT OF COPRECIPITATE FORMATION AND CERTAIN NON-IONIC SURFACTANTS ON CHLORDIAZEPOXIDE RELEASE FROM CAPSULES

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Last updated: 04 Jan 2025

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Abstract

The solvent method was employed to prepare coprecipitates with certain carriers and the water-insoluble drug chlordiazepoxide to enhance its dissolution rate. The investigated carrierswere: poly-ethylene glycol 4000 (PEG 4000), polyvinylpyrrolidone 44000 (PVP 44000) and a-cyclodextrin (a-CYC) in ratios 1:1, 1:3 and 1:7 (drug: carrier), respectively. The dissolution rate of chlordiazepoxide from its prepared coprecipitates using the previously mentioned carriers, especially a-CYC, was found to be higher than that of the drug alone in 0.1N HCl as a dissolution medium. The effect of certain non-ionic surfactant solutions including Brih 35 and Eumulgin C1000 on the release of chlordiazepoxide from the prepared coprecipitates was also investigated. It was found that the investigated surfactants in the concentration used (0.1% W/V), produced better drug release than the control, especially when PEG 4000 was used as a carrier. The mode of interaction taking place between chlordiazepoxide and the investigated carriers was studied by different techniques including UV, IR, chromatography and differential thermal analysis, where a complex formation between chlordiazepoxide and coprecipitating agents was revealed.

DOI

10.21608/bfsa.1986.74474

Authors

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

Aly

Last Name

Abdel Rahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

E.

Last Name

Samy

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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Volume

9

Article Issue

1

Related Issue

11257

Issue Date

1986-06-01

Receive Date

1986-01-22

Publish Date

1986-06-30

Page Start

40

Page End

59

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 1_Pages 40-59.pdf

PDF . 610.2kB

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https://bpsa.journals.ekb.eg/article_74474.html

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https://bpsa.journals.ekb.eg/service?article_code=74474

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF COPRECIPITATE FORMATION AND CERTAIN NON-IONIC SURFACTANTS ON CHLORDIAZEPOXIDE RELEASE FROM CAPSULES

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Article

Created At

22 Jan 2023