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74471

FORMULATION AND EVALUATION OF TRIMETHOPRIM-SULFAMETHOXAZOLE SUPPOSITORIES

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Last updated: 25 Dec 2024

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Abstract

Suppositories containing a mixture of trimethoprim (80 mg) and sulfamethoxazole (400 mg) per each were prepared using the fusion method. Witepsol H15 with and without 10% Tween 60 as the mixture of PEG 6000, 4000, 1540 (47:33:20) were used as suppository bases. The physice-chemical properties, in-vitro and in-vivo availability were investigated. The amount of drug released showed that Witepsol H15 with 10% Tween 60 gave the highest amount of SMZ and TMP released. Meanwhile, no much difference has been found in case of suppositories made with Witepsol H15 and the mixture of PEG bases. This indicated that the incorporation of Tween 60 in 10% concentration has a great role in enhancing the release properties of both drugs. The bioavailability study has proved the same findings of the in-vitro investigations, as it was found that Witepsol H15 incorporated with surfactant was the most suitable base for the preparation of TMP-SMZ suppositories.

DOI

10.21608/bfsa.1986.74471

Authors

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A.

Last Name

Abd El-Gawad

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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First Name

E.

Last Name

Ramadan

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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First Name

A.

Last Name

Nouh

MiddleName

T.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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Volume

9

Article Issue

1

Related Issue

11257

Issue Date

1986-06-01

Receive Date

1986-01-18

Publish Date

1986-06-30

Page Start

25

Page End

39

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 9_Issue 1_Pages 25-39.pdf

PDF . 460.1kB

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https://bpsa.journals.ekb.eg/article_74471.html

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https://bpsa.journals.ekb.eg/service?article_code=74471

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

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https://bpsa.journals.ekb.eg/

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FORMULATION AND EVALUATION OF TRIMETHOPRIM-SULFAMETHOXAZOLE SUPPOSITORIES

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Article

Created At

22 Jan 2023