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DISSOLUTION BEHAVIOUR OF METRONIDAZOLE TABLETS

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Last updated: 25 Dec 2024

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Abstract

The dissolution behavior of metronidazol tablets from three locally manufactured brands on the Egyptian market was studied. Four batches from each brand were collected from the market. The compliance of the tablets collected to the USP XX requirements was evaluated. Some batches from certain brands sis not pass the USP XX requirements for disintegration time, potency and weight variation. The USP XX paddle method was used for the dissolution studies. 0.1 N HCl at 37°C was used as the dissolution medium. Nine tablets from each batch were considered in the dissolution study. The results revealed significant differences among and within the batches of the same brand for the percent metronisazole dissolved after 10, 30 and 105 minutes at p£ 0.1 significance level. Moreover a significant difference was found to exist between different brands. The dissolution rate of drug powder was found to be higher than that of tablets. Furthermore, the drug powder filled into capsules showed higher dissolution behaviour than tablets and lesser than drug powder. In addition, the bioavailability of the drug powder filled into capsules as well as tablets, was studied. The results revealed that there was a correlation between the in-vitro dissolution rate of the drug and its in-vivo absorption data. 

DOI

10.21608/bfsa.1987.74400

Authors

First Name

E.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

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Orcid

-

First Name

S.

Last Name

Tous

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

T.

Last Name

El-Faham

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

10

Article Issue

2

Related Issue

11236

Issue Date

1987-12-01

Receive Date

1987-03-04

Publish Date

1987-12-31

Page Start

123

Page End

138

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 10_Issue 2_Pages 123-138.pdf

PDF . 509.3kB

Link

https://bpsa.journals.ekb.eg/article_74400.html

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https://bpsa.journals.ekb.eg/service?article_code=74400

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9

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DISSOLUTION BEHAVIOUR OF METRONIDAZOLE TABLETS

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Article

Created At

22 Jan 2023