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74398

SPECTROFLUOROMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF SOME TERTIARY AMINE DRUGS

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Last updated: 25 Dec 2024

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Abstract

Seventeen drugs belonging to different pharmacological groupings have been determined either in pure form or in pharmaceutical formulations by spectrophotometry and spectrofluormetry. The method involves the condensation of malonic acid with acetic anhydride under the catalysis of a tertiary amine group in an aliphatic or a heterocyclic system. The product of condensation reaction is highly fluorescent and allows the spectrofluorometric determination of drug containing such groups in the ng/ml ranges (lex=415nm, lem=455 nm).The product of condensations also coloured and allows the spectrophotometric determination of these tertiary amine drugs (lmax=333nm). Results of analyses of pure drugs and their dosage forms by the proposed methods are in good agreement with those of the official B.P. and U.S.P. procedures.

DOI

10.21608/bfsa.1987.74398

Authors

First Name

I.

Last Name

Refaat

MiddleName

H.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

M.

Last Name

El-Kommos

MiddleName

E.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

-

Orcid

-

First Name

H.

Last Name

Farag

MiddleName

H.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

N.

Last Name

El-Rabat

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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-

Orcid

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Volume

10

Article Issue

2

Related Issue

11236

Issue Date

1987-12-01

Receive Date

1987-11-28

Publish Date

1987-12-31

Page Start

85

Page End

102

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 10_Issue 2_Pages 85-102.pdf

PDF . 494.5kB

Link

https://bpsa.journals.ekb.eg/article_74398.html

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https://bpsa.journals.ekb.eg/service?article_code=74398

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPECTROFLUOROMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF SOME TERTIARY AMINE DRUGS

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Article

Created At

22 Jan 2023