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74397

SPECTROPHOTOMETRIC DETERMINATION OF SOME HALOGENATED 8-HYDROXYQUINOLINES WITH ZIRCONYL CHLORIDE

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Last updated: 25 Dec 2024

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Abstract

A spectrophotometric method is described for the determination of 8-hydroxyquinoline (oxine) and three of its halogenated derivatives: 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol), 5,7-diiodo-8- hydroxyquinoline (iodoquinol) and 7-iodo-8- hydroxyl-5-quinoline sulphonic acid (chiniofon). The method involves the use of zirconyl chloride in methanolic medium to give highly absorbing chelates with lmax at 364 nm (oxine), 367 nm (chiniofon), or 389 nm (clioquinol and iodoquinol). The molar ratio of the reaction was established and the characteristic features of the IR spectra of the chelates were discussed. The procedure described was applied successfully to the determination of the named compounds in dosage forms and the results obtained were comparable with official methods.

DOI

10.21608/bfsa.1987.74397

Authors

First Name

I.

Last Name

Refaat

MiddleName

H.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

M.

Last Name

El-Kommos

MiddleName

E.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

H.

Last Name

Farag

MiddleName

H.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

N.

Last Name

El-Rabat

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

Orcid

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Volume

10

Article Issue

2

Related Issue

11236

Issue Date

1987-12-01

Receive Date

1987-11-28

Publish Date

1987-12-31

Page Start

71

Page End

84

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 10_Issue 2_Pages 71-84.pdf

PDF . 432.9kB

Link

https://bpsa.journals.ekb.eg/article_74397.html

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https://bpsa.journals.ekb.eg/service?article_code=74397

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC DETERMINATION OF SOME HALOGENATED 8-HYDROXYQUINOLINES WITH ZIRCONYL CHLORIDE

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Article

Created At

22 Jan 2023