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74394

SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA

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Last updated: 25 Dec 2024

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Abstract

A selective spectrophotometric method is developed for the quantitative determination of levodopa. The proposed method is based on the interaction of levodopa with thiosemicarbazide in an alkaline medium to form a red coloured product. At the maximum absorption of 500 nm, Beer's law is adhered to over the 0-5-8 mg/ml range. Mglar absorptivity of the coloured product is 2.58 x 104. Job's indicates 1:2 ratio of levodopa to thiosemicarbazide. Resulrs of analysis of larodopa tablets by the proposed method agree well with those of U.S.P.XXI. The method is highly selective since a catecholic function with free adjacent positions is required. 

DOI

10.21608/bfsa.1987.74394

Authors

First Name

M.

Last Name

El-Kommos

MiddleName

E.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

10

Article Issue

2

Related Issue

11236

Issue Date

1987-12-01

Receive Date

1987-09-02

Publish Date

1987-12-31

Page Start

34

Page End

46

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 10_Issue 2_Pages 34-46.pdf

PDF . 355.0kB

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https://bpsa.journals.ekb.eg/article_74394.html

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https://bpsa.journals.ekb.eg/service?article_code=74394

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA

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Article

Created At

22 Jan 2023