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74393

COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS. 4- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND F, R AND X PARAMETERS OF RING SUBSTITUENTS

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Last updated: 25 Dec 2024

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Abstract

Colorimetric determination of phenothiazines with NBS in strong sulfuric acid solution has been previously reported (6, 7). Correlation of log emax with  and 2cv parameters of C-2 and N-10 substituents is highly significant only on absence of vulnerable groups at C-2 position. Log emax of four compounds with the same N-10 side chain was correlated with Á parameters of C-2 substituents irrespective of their vulnerability to the reagents. Correlation equations were used to predict the electronic parameters Á, and sp of –SO2N(CH3)2 from the spectrophotometric reaction model. 

DOI

10.21608/bfsa.1987.74393

Authors

First Name

M.

Last Name

El-Kommos

MiddleName

E.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

Youssef

MiddleName

F.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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Volume

10

Article Issue

2

Related Issue

11236

Issue Date

1987-12-01

Receive Date

1987-07-12

Publish Date

1987-12-31

Page Start

21

Page End

33

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 10_Issue 2_Pages 21-33.pdf

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https://bpsa.journals.ekb.eg/article_74393.html

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https://bpsa.journals.ekb.eg/service?article_code=74393

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Original Article

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1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS. 4- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND F, R AND X PARAMETERS OF RING SUBSTITUENTS

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Article

Created At

22 Jan 2023