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74050

FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES

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Last updated: 04 Jan 2025

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Abstract

Chlordiazepoxide hydrochloride (CDZ); is formulated in different suppository bases. Its in vitro release from these selected suppository bases was studied and found to be base dependent. The effect of drug concentration was also studied. The percentage of drug diffused, through cellophane membrane, increased with decreasing the drug concentration. Drug particle size was found to have an insignificant effect on the release rate. Histological studies of the rabbit rectal mucosa after the rectal insertion of the tested suppository bases either alone or in the presence of CDZ showed insignificant histological changes.

DOI

10.21608/bfsa.1987.74050

Authors

First Name

F.

Last Name

Habib

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

-

First Name

H.

Last Name

Sayed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Shaker

MiddleName

-

Affiliation

Department of Histology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Shaker

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

10

Article Issue

1

Related Issue

11202

Issue Date

1987-06-01

Receive Date

1987-06-05

Publish Date

1987-06-30

Page Start

123

Page End

145

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 10_Issue 1_Pages 123-145.pdf

PDF . 791.3kB

Link

https://bpsa.journals.ekb.eg/article_74050.html

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https://bpsa.journals.ekb.eg/service?article_code=74050

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES

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Article

Created At

22 Jan 2023