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74048

KINETICS OF ASPRIN HYDROLYSIS IN AQUEOUS SOLUTIONS OF SURFACTANTS. III: SODIUM LAURYL SULFATE

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Last updated: 04 Jan 2025

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Abstract

The hydrolysis of aspirin solution at a variety of pH values  and in presence of increasing concentrations of sodium lauryl sulfate (SLS) was investigated at 35°C. The hydrolysis followed first order kinetics. The results indicate that the presence of sodium lauryl sulfate results in a protection of aspirin against hydrolysis and the degree of protection was found to be dependent on the surfactant concentration. This finding was explained on the basis that as the surfactant concentration was increased, aspirin was distributed in a favour of the micellar phase and the amount of aspirin exists in the true aqueous phase, which is susceptible to hydrolysis, is reduced. Also, the data revealed that the presence of sodium layryl sulfate did not alter the optimum pH value for the stability of aspirin solution which was found to be 2.4. 

DOI

10.21608/bfsa.1987.74048

Authors

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S.

Last Name

Ismail

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

A.

Last Name

Simonelli

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P.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, University of Connecticut , Storrs, CT. 06268, USA

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Volume

10

Article Issue

1

Related Issue

11202

Issue Date

1987-06-01

Receive Date

1987-09-09

Publish Date

1987-06-30

Page Start

112

Page End

122

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 10_Issue 1_Pages 112-122.pdf

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https://bpsa.journals.ekb.eg/article_74048.html

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https://bpsa.journals.ekb.eg/service?article_code=74048

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

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https://bpsa.journals.ekb.eg/

MainTitle

KINETICS OF ASPRIN HYDROLYSIS IN AQUEOUS SOLUTIONS OF SURFACTANTS. III: SODIUM LAURYL SULFATE

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Article

Created At

22 Jan 2023