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74047

ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES II. MYRJS AND BRIJS

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Last updated: 04 Jan 2025

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Abstract

The permeation rate constant of rifampicin in presence of Hyrj 52, Myrj 53, Myrj 59, Brij 35 and Brij 58 was studied utilizing the dynamic dialysis technique. The presence of Myris or Brij in rifampicin solution markedly decreased the permeation rate constant. Generally, the apparent transfer rate constant is inversely proportional to the surfactant concentration. The most reducing effect was exhibited in case of Brij 35. This may be due to a high affinity of the drug to interact with this surfactant than the other tested ones. The Langmuir plots for the interaction between rifampicin and surfactant showed g-intercept indicating that the complex formation is a factor in the binding of rifampicin by surfactants. Furthermore, the presence of surfactant in rifampicin solution was found to reduce its antibacterial activity against S. aureus.

DOI

10.21608/bfsa.1987.74047

Authors

First Name

S.

Last Name

Ismail

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-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

F.

Last Name

Habib

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

Orcid

-

First Name

S.

Last Name

El-Shanawany

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

E.

Last Name

Fouad

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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-

Orcid

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Volume

10

Article Issue

1

Related Issue

11202

Issue Date

1987-06-01

Receive Date

1987-05-06

Publish Date

1987-06-30

Page Start

95

Page End

111

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 10_Issue 1_Pages 95-111.pdf

PDF . 437.8kB

Link

https://bpsa.journals.ekb.eg/article_74047.html

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https://bpsa.journals.ekb.eg/service?article_code=74047

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES II. MYRJS AND BRIJS

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Article

Created At

22 Jan 2023