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PHARMACOLOGICAL EVALUATION OF SOME OXAMIDE DERIVATIVES ON CEREBRAL ACTIVITY

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Last updated: 04 Jan 2025

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Abstract

The present study was adopted in an attempt to evaluate the anticonvulsant and central epressant activity of five N-substituted-N-(2-methyl-4-oxoquinazolin-3-yl) oxamides. The anticonculsant activity was determined against both electroshock and pentyleneterazole induced seizures in mice. The CNS deperessant activity was indicated by measuring their effect on the spontaneous motor activity of mice using the activity cage apparatus. Diazepam was used in the experiments as a reference drug for comparative purpose. Results of the present study revealed that most of the compounds in question possess variable degree of anticonvulsant and CNS depressant activity and the compound N-Isopropyl-N-(2-methyl-4-0x0quinazolin-3-yl) oxamide displayed the greatest response. Intraperitoneal injection of this compound into rabbits has not led to any remarkable change in the ECG, blood pressure or respiration. However on weight basis the magnitude f diazepam response is greater than any of the tested compounds.

DOI

10.21608/bfsa.1987.74045

Authors

First Name

H.

Last Name

El-Bitar

MiddleName

I.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Orcid

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First Name

R.

Last Name

Abdel Aal

MiddleName

A.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Volume

10

Article Issue

1

Related Issue

11202

Issue Date

1987-06-01

Receive Date

1987-03-15

Publish Date

1987-06-30

Page Start

84

Page End

94

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 10_Issue 1_Pages 84-94.pdf

PDF . 411.8kB

Link

https://bpsa.journals.ekb.eg/article_74045.html

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https://bpsa.journals.ekb.eg/service?article_code=74045

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PHARMACOLOGICAL EVALUATION OF SOME OXAMIDE DERIVATIVES ON CEREBRAL ACTIVITY

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Article

Created At

22 Jan 2023