Beta
ManageSearchChatDiscover
73520

DISSOLUTION BEHAVIOUR OF PROPYLTHIOURACIL POLYVINYLPYRROLIDONE SOLID DISPERSIONS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The objective of the present study was to investigate the influence of variation of the molecular weight and the proportion of polyvinylpyrrolidone (PVPs) on the dissolution of propylthiouracil (Pt) as a model of sparingly soluble drugs dispersed in highly soluble polymers. Solid dispersions of Pt-PVP were prepared by the solvent method. The dissolution behavior was determined as a function of the molecular weight of PVP and the drug-to-carrier ratio. Three PVP molecular weight fractions were used, namely, PVP 10.000, PVP 40.000 and PVP 360.000. The drug-PVP percentages used were 10, 20, 40, 60 and 90%w/w. Enhancement of dissolution rate was observed for all solid dispersion systems compared to the drug alone or the physical mixtures. The dissolution rate was increased with increasing the proportion of PVP to the drug. Generally, the enhancement of the dissolution rate was decreased in the order: PVP 10.000 > PVP 40.000 > PVP 360.000. Differential scanning calorimetry (DSC) reveals a decrease in the melting point of Pt due to retardation of drug nucleation in the PVP matrix. X-ray diffractometry of the highest dissolution rate solid dispersion indicates the presence of Pt in an amorphous state in the carrier.

DOI

10.21608/bfsa.1988.73520

Authors

First Name

S.

Last Name

Abdel-Rahman

MiddleName

I.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

El-Sayed

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

11

Article Issue

2

Related Issue

11134

Issue Date

1988-12-01

Receive Date

1988-11-02

Publish Date

1988-12-31

Page Start

261

Page End

272

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 11_Issue 2_Pages 261-272.pdf

PDF . 426.6kB

Link

https://bpsa.journals.ekb.eg/article_73520.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=73520

Order

8

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DISSOLUTION BEHAVIOUR OF PROPYLTHIOURACIL POLYVINYLPYRROLIDONE SOLID DISPERSIONS

Details

Type

Article

Created At

22 Jan 2023