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73518

AVAILABILITY OF PHENYLEPHRINE HYDROCHLORIDE FROM OPHTHALMIC MULTIPLE EMULSIONS

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Last updated: 25 Dec 2024

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Abstract

Phenylephrine hydrochloride was formulated in different emulsion systems with and without viscolizers (methylcellulose and tylose). The diffusion coefficient of phenylephrine hydrochloride in different formulation has been determined. Results indicated that the diffusion coefficient of Phenylephrine hydrochloride from different systems decreased with increasing viscolizer concentration. The mydriatic and intraocular pressure, IOP, responses were followed after the application of the tested formulations to the rabbit's eye. Four parameters have been utilized to assess the performance of the drug formulations. These are the area under the curve AUC; the maximum response, MR; the time of maximum response. TMR; and the duration of drug action. DA. It was found that the most effective emulsion system appeared to be the multiple w/o/w emulsion containing 1% w/v methylcellulose followed by that containing 0.5% w/v tylose.

DOI

10.21608/bfsa.1988.73518

Authors

First Name

A.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

-

Orcid

-

First Name

F.

Last Name

Habib

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

M.

Last Name

Attia

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

11

Article Issue

2

Related Issue

11134

Issue Date

1988-12-01

Receive Date

1988-10-25

Publish Date

1988-12-31

Page Start

248

Page End

260

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 11_Issue 2_Pages 248-260.pdf

PDF . 430.0kB

Link

https://bpsa.journals.ekb.eg/article_73518.html

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https://bpsa.journals.ekb.eg/service?article_code=73518

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

AVAILABILITY OF PHENYLEPHRINE HYDROCHLORIDE FROM OPHTHALMIC MULTIPLE EMULSIONS

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Article

Created At

22 Jan 2023