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73516

ANALYSIS OF SOME ANTI-INFLAMMATORY ARYLACETIC ACID DERIVATIVES THROUGH THE GRIESS REACTION

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Last updated: 25 Dec 2024

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Abstract

A simple, rapid and accurate method for the spectrophotometric determination of six anti-inflammatory arylacetic acid derivatives (Ibuprofen, naproxen, ketoprofen, indomethacin, pirprofen and flurbiprofen) in either the drug susbstances or in pharmaceutical formulations is proposed. The method is based on the development of the characteristic orange Griess pigment with sodium nitrite p-nitroaniline and 1-naphylamine. A linear correlation was found between absorbance at lmax of 470 nm and concentration. The colour is well developed by heating the mixture of the drug and reagents on a water-bath at 60°C dor 15 minutes. The resulting chromogen is stable for at least 12 hours. Results of analysis of the official (first three) compounds is bulk drugs and dosage forms are in good agreement with those of the B.P 1980 procedures.

DOI

10.21608/bfsa.1988.73516

Authors

First Name

M.

Last Name

El-Kommos

MiddleName

E.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

K.

Last Name

Emara

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Volume

11

Article Issue

2

Related Issue

11134

Issue Date

1988-12-01

Receive Date

1988-07-25

Publish Date

1988-12-31

Page Start

222

Page End

234

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 11_Issue 2_Pages 222-234.pdf

PDF . 411.7kB

Link

https://bpsa.journals.ekb.eg/article_73516.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=73516

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ANALYSIS OF SOME ANTI-INFLAMMATORY ARYLACETIC ACID DERIVATIVES THROUGH THE GRIESS REACTION

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Article

Created At

22 Jan 2023