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73513

DISSOLUTION ENHANCEMENT OF THIACETAZONE I: VIA SURFACE HYDROPHILIZATION

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Last updated: 25 Dec 2024

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Abstract

Hydrophilized systems of thiacetazone with different hydrophilic Viz., surfactants, polymers, sugar alcohols and isoniazid were prepared. The tested drug was intimately wetted with small volume of alcoholic carrier solution, and left aside to dry at room temperature. The wettability and dissolution rate tests of the hydrophilized systems and their corresponding physical mixtures were performed. Also, the effect of the tested carriers on the aqueous solubility of thiacetazone was investigated. The USPXX dissolution test, exhibited a pronounced increase in dissolution of thiacetazone from its hydrophilized systems as compared to that of their physical mixtures and pure drug. Generally, a direct correlation was found between the wettability and dissolution rates.  Hydrophilized systems with surfactants gave the highest dissolution and good wettability next to isoniazid. Surfactants then followed in order by sugar alcohols and then by polymers. The effect of surfactants is directly proportional to the concentration. After 10 minutes the relative dissolution rate was 14.34, 13.86 or 14.43 for 5% w/w. Tween 40, 60 or Myrj 53 respectively. However, with the other carriers higher concentrations led to reduction in the dissolution enhancing effect. The results denote the potential use of this technique to enhance thiacetazone dissolution. 

DOI

10.21608/bfsa.1988.73513

Authors

First Name

S.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

E.

Last Name

Hafez

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

T.

Last Name

El-Faham

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

F.

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

11

Article Issue

2

Related Issue

11134

Issue Date

1988-12-01

Receive Date

1988-06-20

Publish Date

1988-12-31

Page Start

196

Page End

221

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 11_Issue 2_Pages 196-221.pdf

PDF . 813.3kB

Link

https://bpsa.journals.ekb.eg/article_73513.html

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https://bpsa.journals.ekb.eg/service?article_code=73513

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DISSOLUTION ENHANCEMENT OF THIACETAZONE I: VIA SURFACE HYDROPHILIZATION

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Article

Created At

22 Jan 2023