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73485

SPECTROPHOTOMETRIC ASSAY OF CERTAIN BENZODIAZEPINE DRUGS THROUGH COMPLEX FORMATION REACTION

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Last updated: 25 Dec 2024

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Abstract

A simple and accurate spectrophotometric method was developed for the determination of diazepam, prazepam and flunitrazepam. The method is based on the interaction of the benzodiazepine drug containing an active methylene group with 1,3-dinitrobenzene in presence of tetraethylammonium hydroxide to form a violet coloured d-complex (lmax=560 nm). Beer's law is obeyed over the concentration ranges 2-20 mg ml-1 (for diazepam), 5-30 mg ml-1 (for prazepam) and 5-40 mg ml-1 (for flunitrazepam). The method was successfully applied to the assay of the cited drugs in pure form and in pharmaceutical formulations. Results obtained agree well with those of official methods.

DOI

10.21608/bfsa.1988.73485

Authors

First Name

Michael

Last Name

El-Kommos

MiddleName

E.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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City

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Orcid

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First Name

Kamla

Last Name

Emara

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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Volume

11

Article Issue

1

Related Issue

11092

Issue Date

1988-06-01

Receive Date

1988-05-04

Publish Date

1988-06-30

Page Start

141

Page End

153

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 11_Issue 1_Pages 141-153.pdf

PDF . 439.9kB

Link

https://bpsa.journals.ekb.eg/article_73485.html

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https://bpsa.journals.ekb.eg/service?article_code=73485

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9

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC ASSAY OF CERTAIN BENZODIAZEPINE DRUGS THROUGH COMPLEX FORMATION REACTION

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Article

Created At

22 Jan 2023